Synopsis
The BioSAXS beamline is a highly automated beamline dedicated to the study of proteins, macromolecular complexes, viruses etc., in solution. Samples can be investigated under various conditions (temperature, buffer, pH, kinetics) in a high-throughput manner or a HPLC unit can be used for in-situ (online) purification.
Status:
open
Disciplines
- Life Sciences
- Chemistry
- Medicine
Applications
- Structural biology
- Pharmaceuticals
Techniques
-
BioSAXS - small-angle X-ray scattering (proteins/DNA)
-
SAXS - small-angle X-ray scattering
Beam size
- Minimum (H x V) : 50.0
x 50.0
µm²
-
Maximum (H x V) : 2.0
x 1.0
mm²
Sample environments
- Quartz capillary as a part of automated sample changer allowing temperature variations (from 4 to 60°C)
- HPLC (high performance liquid chromatography) system can be used in parallel with sample changer
Detectors
Pernot P., Theveneau P., Giraud T., Nogueira Fernandes R., Nurizzo D., Spruce D., Surr J., McSweeney S., Round A., Felisaz F., Foedinger L., Gobbo A., Huet J., Villard C. and Cipriani F., "New beamline dedicated to solution scattering from biological macromolecules at the ESRF", Journal of Physics: Conference Series 247 (2010) 012009-1-012009-8.
Chameleonic amphiphile: The unique multiple self-assembly properties of a natural glycolipid in excess of water
Baccile N., Poirier A., Seyrig C., Le Griel P., Pérez J., Hermida-Merino D., Pernot P., Roelants S.L.K.W., Soetaert W.,
Journal of Colloid and Interface Science 630, 404-415 (2023)
EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
Bademosi A.T., Decet M., Kuenen S., Calatayud C., Swerts J., Gallego S.F., Schoovaerts N., Karamanou S., Louros N., Martin E., Sibarita J.B., Vints K., Gounko N.V., Meunier F.A., Economou A., Versées W., Rousseau F., Schymkowitz J., Soukup S.F., Verstreken P.,
Neuron 111, 1402-1422 (2023)
The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein
Batista M., Donker E.I.M., Bon C., Guillien M., Caisso A., Mourey L., François J.M., Maveyraud L., Zerbib D.,
Journal of Molecular Biology 435, 168048-1-168048-20 (2023)
Pathways of membrane solubilization: A structural study of model lipid vesicles exposed to classical detergents
Bjørnestad V.A., Lund R.,
Langmuir 39, 3914-3933 (2023)
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin
Bonhomme S., Contreras-Martel C., Dessen A., Macheboeuf P.,
Structure , epub (2023)
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins
Gallego P., García-Bonete M.J., Trillo-Muyo S., Recktenwald C.V., Johansson M.E.V., Hansson G.C.,
Nature Communications 14, 1969-1-1969-9 (2023)
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