Synopsis
The BioSAXS beamline is a highly automated beamline dedicated to the study of proteins, macromolecular complexes, viruses etc., in solution. Samples can be investigated under various conditions (temperature, buffer, pH, kinetics) in a high-throughput manner or a HPLC unit can be used for in-situ (online) purification.
Status:
open
Disciplines
- Life Sciences
- Chemistry
- Medicine
Applications
- Structural biology
- Pharmaceuticals
Techniques
-
BioSAXS - small-angle X-ray scattering (proteins/DNA)
-
SAXS - small-angle X-ray scattering
Beam size
- Minimum (H x V) : 50.0
x 50.0
µm²
-
Maximum (H x V) : 2.0
x 1.0
mm²
Sample environments
- Quartz capillary as a part of automated sample changer allowing temperature variations (from 4 to 60°C)
- HPLC (high performance liquid chromatography) system can be used in parallel with sample changer
Detectors
Pernot P., Theveneau P., Giraud T., Nogueira Fernandes R., Nurizzo D., Spruce D., Surr J., McSweeney S., Round A., Felisaz F., Foedinger L., Gobbo A., Huet J., Villard C. and Cipriani F., "New beamline dedicated to solution scattering from biological macromolecules at the ESRF", Journal of Physics: Conference Series 247 (2010) 012009-1-012009-8.
Annexin A11 C-terminal domain reveals calcium-dependent co-binding to RNA and lipid vesicles
Alfurno L., Raccuia E., Di Napoli G., Fissore A., Tully M.D., Bincoletto V., Arpicco S., Scoccia R., Martina K., Marengo M., Oliaro-Bosso S., Manzoli M., Prischi F., De Simone A., Di Palma F., Spyrakis F., Adinolfi S.,
International Journal of Biological Macromolecules 376, 153226-1-153226-9 (2026)
Single-chain polymer nanoparticles for oil solubilization
Arena D., Miranda J.I., Lutz-Bueno V., Moreno A.J., Pomposo J.A., de Molina P.M.,
Journal of Colloid and Interface Science 704, 139395-1-139395-9 (2026)
Dimer asymmetry in signaling of blue light sensor histidine kinases
Arinkin V., Stadler A.M., Meier S.S.M., Jaeger K.E., Möglich A., Krauss U., Batra-Safferling R.,
Science Advances 12, eaed8943-1-eaed8943-19 (2026)
Toward nanodisc tailoring for SANS study of membrane proteins
Batchu K.C., Tully M.D., Martel A.,
Bioengineering 13, 87-1-87-15 (2026)
Conformational flexibility and transient structure of the proline-rich domain in p53
Berggren A., Bakker M., Fisher H., Skepö M.,
Biophysical Journal 125, 1914-1925 (2026)
Ligands reshape the compactness, stability, and topology of telomeric G-quadruplex dimers
Bertini L., Libera V., Arciuolo V., Trapella M., Marzano S., Mostarac D., Schirò G., Petrillo C., Giancola C., De Michele C., Amato J., Comez L., Pagano B., Paciaroni A.,
Nucleic Acids Research 54, gkag403-1-gkag403-14 (2026)
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