All SOS requests (either starting from liquid or grids) should be associated with the SOSquestions document for technical feasibility evaluation. The document should be sent by email to

Sample Quality required:

  • Size-exclusion purified protein or protein complexes
  • Stability characterization including DLS, SEC-MALLS, etc
  • Freeze-thaw SEC profiles

Computing infrastructure required in host lab:

  • Access to cryoEM image processing software
  • Access to GPU/CPU clusters
  • Preferably proven cases of determining cryoEM structures