ID23-2: Microfocus Macromolecular Crystallography

Synopsis

ID23-2 is a fixed energy beamline dedicated to MX. ID23-2 offers a standard MX sample environment, but with a focused microbeam (10x4 micron).

Status: open

Disciplines

Life Sciences

Applications

Macromolecular crystallography

Techniques

MX - macromolecular crystallography
Microbeam

Energy range

14.2 keV

Beam size

Minimum (H x V) : 1.0 x 2.0 µm²
Maximum (H x V) : 8.0 x 25.0 µm²

Sample environments

Microdiffractometer MD3Up
UNIPUCK+SPINE pins only (no SC3)

Detectors

DECTRIS EIGER X 9M

Technical details

This beamline offers diffraction data collection on microcrystalline MX samples and on fine needle MX samples, as well as determination of the region of highest diffraction quality from larger MX samples.

ID23-2: an automated and high-performance microfocus beamline for macromolecular crystallography at the ESRF

Latest publications

View all publications

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

Amann M., Strässer T., Einsle O., Günther S.,
Protein Science 35, e70614-1-e70614-12 (2026)

Structures of variants of Escherichia coli flavodiiron-type nitric oxide reductase reveal changes in the di-iron site

Borges P.T., Folgosa F., Martins M.C., Gotthard G., van der Linden P., Carpentier P., Teixeira M., Frazão C., Romão C.V.,
Acta Crystallographica D 82, 457-470 (2026)

An improved nerve agent bioscavenger based on the fast self‐reactivation mechanism of porcine butyrylcholinesterase

Brazzolotto X., Lushchekina S., Nachon F.,
Protein Science 35, e70467-1-e70467-26 (2026)

KRAS can bind to FTase despite disruption of the CAAX binding site

Carion M., Cuesta R., Kowalczyk D., Smets W., Soons E., Klaassen H., Vanderhoydonck B., Marchand A., Versele M., Chaltin P., Dedecker P., Park H., Ismail S.,
Biochemistry 65, 521-526 (2026)

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Cheng X.F., Lucas B., Lampe P., Ugel S., Chen S., Unger A., Bischoff M., Adariani S.R., Naredla K.R., Kumar K., Schmidt A., Strohmann C., Janning P., Gasper R., Lucas M., Gersch M., Sievers S., Bronte V., Ziegler S., Waldmann H.,
Angewandte Chemie International Edition 65, e18753-1-e18753-16 (2026)

Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase

de Sousa J., Calas A.G., de la Mora E., Landry C., Hanak A.S., Maryan-Instone A., Gastellier A.J., Coisne C., Courageux C., Hachani J., Gosselet F., Dehouck M.P., Rousseau C., Timperley C.M., Weik M., Nachon F., Brown R.C.D., Baati R., Dias J.,
European Journal of Medicinal Chemistry 316, 119023-1-119023-17 (2026)

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