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2-4 June, 2008
Venue: ESRF Auditorium

MONDAY
June 2nd, 2008
08:30-09:00 Registration

SESSION 1
CELLULAR AND TISSULAR EFFECTS OF RADIATION
(INCLUDING SPECIFIC RESPONSE TO MRT)

International Committee Advisors:
Jean Laissue, Jacques Balosso

Chair: Jacques Balosso

09:00-09:10 Welcome Sine Larsen, Research Director
ESRF, Grenoble, France
09:10-09:35 Introduction Alberto Bravin
ESRF, Grenoble, France
09:35-10:05 Diffuse intrinsic pontine glioma: pathophysiological and clinical aspects of a pediatric brain tumor resistant to current therapies Michael Grotzer
University Children's Hospital of Zurich, Switzerland
10:05-10:35 Modern radiotherapy in brain tumours: concepts and techniques Beate Timmermann
Paul Scherrer Institute, Villigen, Switzerland
10:35-11:05 Coffee break
11:05-11:25 Stereotactic Synchrotron Radiation Therapy, from first concepts to preclinical results and towards clinical trials François Estève
ESRF & INSERM, Grenoble, France
11:25-11:45 Microbeam radiation therapy (MRT): Milestones - Clinical prospects Jean A. Laissue
Institute of Pathology, University of Bern, Switzerland
11:45-12:15 A nanomedecine perspective for the management of patients with glioblastomas ? François Berger
CHU Grenoble, France
12:15-12:40 Summary and discussion Jacques Balosso
CHU Grenoble, France
12:40-14:10 Lunch at the ESRF restaurant

Chair: Boudewijn van der Sanden

14:10-14:25 Treatment of spontaneous tumors in pet animals as part of the development of a new radiation treatment modality Barbara Kaser-Hotz
Freie Universität Berlin and Animal Oncology and Imaging Center, Switzerland
14:25-14:40 High tolerance of the rat spinal cord to microplanar irradiation Jean A. Laissue
Institute of Pathology, University of Bern, Switzerland
14:40-14:55 Memory and survival after bidirectional MRT: a study in two animal models of malignant brain tumour Elisabeth Schültke
University of Saskatchewan, Canada & University of Liverpool, U.K
14:55-15:10 Normal and tumoral brain vessel response to Microbeam Radiation Therapy Raphaël Serduc
ESRF, Grenoble & CNRS-Université, Toulouse, France
15:10-15:25 X-ray Micro-tomography Image Analysis for quantifying the Impact of Radiotherapy on Brain Vessels Philippe Noriega
Université de Toulouse, France
15:25-15:55 Coffee break
15:55-16:55 Summary and discussion Avraham Dilmanian
Brookhaven National Laboratory, Upton NY, USA
16:55-17:10 Picture of the Workshop Participants
17:10-18:40 Beamline visit
20:00-22:00 POSTER SESSION and "WINE & CHEESE" BUFFET
TUESDAY
June 3rd, 2008

SESSION 2
RADIATION THERAPY SURVIVAL ENHANCEMENT BASED ON COMBINED STRATEGIES:
IMMUNO-PROCESSES, RADIOSENSITISERS, CHEMICALS, DRUG DELIVERY

International Committee Advisors:
Jacques Balosso, Hans-Peter Wagner

Chair: Géraldine Le Duc

09:00-09:30

Clinical potential of microbeam radiosurgery

CANCELLED

Pantaleo Romanelli
IRCCS Neuromed, Pozzilli, IS, Italy
09:30-10:00 The siDNA: a new method to sensitize radioresistant tumors to irradiation Marie Dutreix
Institut P. et M. Curie, Paris, France
10:00-10:15 Cross-planar microbeam irradiation can improve survival rate of rats with C6 glioma Takeshi Kondoh
Kobe University, Japan
10:15-10:30 Nano-IRT : Indirect radiation therapy development with target Nanoparticles Thomas Nawroth
Johannes Gutenberg-University
Mainz, Germany
10:30-10:45 Cell culture tests and electron boost effect in Nano-IRT with synchrotron radiation Natalie Glube
Johannes Gutenberg-University, Mainz, Germany
10:45-11:15 Coffee break
11:15-11:30 Hybrid gadolinium oxide nanoparticles: contrast agents combining diagnosis and therapy Stéphane Roux
Université Claude Bernard, Lyon, France
11:30-11:45 Gold nanoparticles designed for in vivo SRCT and MRI imaging and X-ray therapy Christophe Alric
Université Claude Bernard, Lyon, France
11:45-12:10 Summary and discussion Henry Smilowitz
University of Connecticut Health Center, Farmington, USA
12:10-13:45 Lunch at the ESRF restaurant

Chair: Hans Blattmann

13:45-14:15 Preclinical glioma immunotherapy using advanced rat tumor models Henry Smilowitz
University of Connecticut Health Center, Farmington, USA
14:15-14:30 Synchrotron X-ray chemical microscopy for subcellular study Sylvain Bohic
INSERM & ESRF, Grenoble, France
14:30-14:45 Effects of ionizing radiation on the neurovascular unit : an in vitro study William Fauquette
Centre de Recherches Emile Pardé, La Tronche, France
14:45-15:00 Anti-cancer modalities with synchrotron radiation: a comprehensive overview considering the national context and the available data Nicolas Foray
INSERM, Grenoble, France
15:00-15:30 Coffee break
15:30-15:45 Synergistic Effects of Cisplatin and Synchrotron Irradiation on F98 Gliomas Growing in Nude Mice Clément Ricard
INSERM & Université Joseph Fourier, Grenoble, France
15:45-16-00 Volume reduction of ENU-induced rat brain tumors by irradiation with synchrotron radiation Manuel Fernández
INSERM, Grenoble, France
16:00-16-30 Summary and discussion Hans-Peter Wagner
University Hospitals, Bern, Switzerland
19:30 Bus departure from the ESRF Guesthouse to the restaurant
20:00 Workshop Dinner
22:15 Bus departure from the restaurant to the ESRF Guesthouse
WEDNESDAY
June 4th, 2008

SESSION 3
THEORETICAL AND EXPERIMENTAL DOSIMETRY


International Committee Advisors: Herwig G. Paretzke, Avraham Dilmanian,
José-Maria Fernandez-Varea

Dosimetry measurements and modelling

Chair: José-Maria Fernandez-Varea

09:00-09:30 X-ray microbeam semiconductor dosimetry and modelling Anatoly Rozenfeld
University of Wollongong, Wollongong, Australia
09:30-09:45 Microbeam Radiation Therapy: the challenges in Dosimetry Elke Bräuer-Krisch
ESRF, Grenoble, France
09:45-10:00 MOSFET dosimetry with high spatial resolution in intense synchrotron-generated x-ray microbeams Erik A. Siegbahn
ESRF, Grenoble, France
10:00-10:15 Strip Detector for high spatial resolution dosimetry in microbeam radiation therapy Michael L.F. Lerch
University of Wollongong, Australia
10:15-10:30 Modelling the source and multislit collimator geometry and their influence on MRT microbeam profiles Heidi Nettelbeck
University of Wollongong, Australia
10:30-10:45 Real-time radiation biology at nanometric scale Yann Gauduel
Laboratoire d'Optique Appliquée, CNRS; Palaiseau, France
10:45-11:00 Summary and discussion Herwig G. Paretzke
Technische Universität München, Germany
11:00-11:20 Coffee break
Processes in Synchrotron-Photon fields

Chair: Elke Bräuer-Krisch

11:20-11:40 Track left behind in tissues by photons Herwig G. Paretzke
Technische Universität München, Germany
11:40-11:55 Rayleigh and Compton scattering of 10-100 keV photons. Theoretical models and Monte Carlo simulation Immaculada Martínez-Rovira
Universitat Politècnica de Catalunya, Barcelona, Spain
11:55-12:10 Secondary electron tracks generated by synchrotron radiation in water Gustavo Garcia
Instituto de Fisica Fundamental, Madrid, Spain
12:10-12:25 Assessment of radiation quality by means of nanodosimetric quantities Elisabetta Gargioni
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany
12:25-12:40 Dose-enhancement from high Z elements: The importance of dosimetry in complex biological systems Hélène Elleaume
ESRF & INSERM, Grenoble, France
12:40-13:00 Summary and discussion

Yolanda Prezado
ESRF, Grenoble, France
Paul Berkvens
ESRF, Grenoble, France

13:00-14:15 Lunch at the ESRF restaurant

SESSION 4
APPROACHES FOR SYNCHROTRON RADIATION CLINICAL TRIALS INCLUDING TREATMENT PLANNING SYSTEMS

International Committee Advisor:
Wolfgang Schlegel

Chair: Avraham Dilmanian

14:15-14:35 Development of Treatment planning Systems for innovative Radiotherapy from preclinical to clinical applications

Uwe Oelfke
DFKZ, Heidelberg, Germany

14:35-14:55 Clinical trials projects in SSRT Jacques Balosso
CHU Grenoble, France
14:55-15:10 Dose distribution optimization for synchrotron stereotactic radiotherapy using Monte Carlo simulation Magali Edouard
INSERM, Joseph Fourier University, ESRF, & CHU Grenoble, France
15:10-15:25 Monte-Carlo dosimetry for Stereotactic Synchrotron Radiation Therapy (SSRT) of brain tumors Yolanda Prezado
ESRF, Grenoble, France
15:25-15:55 Coffee break

Chair: Yolanda Prezado

15:55-16:15 MRT-planning (similarities and differences with and between planning for therapy with photons, hadrons and MR) Hans Blattmann
University of Bern, Bern, Switzerland
16:15-16:30 Monte Carlo based treatment planning methods for X-ray microbeam radiotherapy (MRT) Richard P. Hugtenburg
Swansea University
16:30-16:50 Recent results on low energy electron and photon simulation with Geant4 Maria Grazia Pia
INFN, Genova, Italy
16:50-17:10 Boron neutron capture therapy (BNCT) in Finland; clinical trials for malignant gliomas and locally recurred HN carcinoma Leena Kankaanranta
Helsinki Central University Hospital, Finland
17:10-17:30 Summary and discussion Jean-François Adam
Institute of Neuroscience, Grenoble, France
17:30-18:45 Workshop summary and discussion Pekka Suortti
University of Helsinki, Helsinki, Finland
William Thomlinson
Canadian Light Source, Saskatoon, Canada