Structural biology

The evolution of the facility, in the context of the ESRF upgrade, was encompassed within UPBL10/MASSIF.  This facility, located at beamlines ID30 and BM29, has at its core three beamlines optimised for highly automated, high-throughput sample evaluation. Currently, ID29 is being converted to a highly intense beamline dedicated to time-resolved, synchrotron serial crystallography (SSX) experiments.

Many of the world's leading pharmaceutical companies carry out proprietary research on our beamlines developing future drug candidates.  Industrial clients can access our facilities through our mail-in crystallography service MXpress or by applying directly for beamtime.  See the Industry website for details.

In-house research runs in parallel to beamline operation, helping us to perfect techniques while investigating key scientific areas. Current projects include:

• Beamline instrumentation (Kappa gonimeters, dehydration devices, sample characterisation)
• The molecular basis of Alzheimer disease.
• Structural studies of enzymatic transition states.
• Activation mechanisms of LysR transcription regulators.

Additional details are in our Research & Development and Research Profiles pages.

A number of laboratories and facilities are available to the community. Of particular interest is The Partnership for Structural Biology (PSB) which is a collaboration between ESRF, EMBL, ILL and IBS to bring together a set of complementary technologies for structural biology.

• The Partnership for Structural Biology
• in-crystallo optical spectroscopy laboratory (icOS)
• High Pressure Freezing Laboratory (HPMX) 

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