ID17 - Biomedical Beamline

Synopsis

ID17 is dedicated to biomedical imaging, radiation biology and radiation therapy; experiments can be run in-vitro or in-vivo in two endstations of the same line.

Disciplines

• Medicine
• Cultural Heritage
• Life Sciences
• Materials and Engineering

Applications

• Preclinical radiation therapy
• Radiation biology studies
• Preclinical brain microsurgery
• In-vitro phase contrast imaging
• Functional imaging
• Paleontology

Techniques

• Microbeam, minibeam and pencil beam radiation therapy
• Imaging, pink beam
• Imaging, monochromatic
• Stereotactic synchrotron radiation therapy
• Radiography
• Imaging
• Imaging, phase-contrast
• Imaging, K-edge subtraction imaging
• Dosimetry
• ABI - analyser based imaging
• Photon activation therapy
• Imaging, coded aperture
• Imaging, absorption based

Sample environments

• MRT station: Kappa geometry goniometer for sample weights up to 30 kg; Various in-vivo sample holders
• Imaging station: Low- to medium-resolution imaging: high-load positioning system (up to 150 kg). Vertical speed up to 500 mm/s, angular speed up to 0.5 turns/second; High- resolution imaging: large variety of high-resolution linear and rotation stages (Micos, Newport, Huber); Analyzer-based imaging setup including post-monochromator- and analyzer-stage (Si(111) or Si(333), Bragg-geometry) usable in the range 25-70 keV; Rotation stages in a cooled environment for cell irradiations; Low-load platform (35 Kg) for vertical translation (travel 300mm, max. speed 2.5mm/s)
• Annexed laboratories: Cell laboratory (Level 2 confinement); Molecular biology laboratory; Sample preparation laboratory; Preclinical sample preparation laboratory; Histology laboratory

Detectors

• Calibrated PTW dosimetry chambers (covering a wide energy range) and electrometers for dosimetry studies
• MRT station (monochromatic beam and pink beam): FReLoN2000 CCD ; pixel size 23 x 23 µm2
• Imaging station (monochromatic beam only): Taper optics FReLoN 2k CCD camera, field-of-view 95x95 mm2, pixel size 47x47 µm2 (permanently installed); 2-line Ge-detector, 432 pixels/line, field-of-view (hor): 150mm pixel size: 0.35 x 10 mm2 (hor x vert) (permanently installed); Two optical systems to be used with a FReLoN2k camera (non-permanent, installed upon request): (a) field of view 16 mm (hor); pixel size: 8 x 8 µm2; (b) field of view 60 mm (hor); pixel size 30 x 30 µm2

Technical details

ID17 is dedicated to biomedical imaging, radiation biology and radiation therapy; experiments can run in-vitro or in-vivo in two endstations. The first endstation (MRT) uses filtered white beam (40 - 600 keV) for microbeam, minibeam and pencilbeam radiation therapy and image-guided brain microsurgery. The beam can be either spatially homogeneous or spatially fractionated (using a multi-slit collimator). The second endstation (imaging) uses monochromatic X-rays for radiography, microtomography, radiation biology and radiation therapy. Up to 4 monochromators are available, each having its own range of energies and beam sizes. The beamline and annexed laboratories deal with scales from cell samples up to human patients. Imaging modes include absorption, time-resolved, K-edge substraction, phase contrast: propagation based, analyzer based, coded aperture. Both radiography and tomography can be done with time resolution. APPLICATIONS: Examples of applications include preclinical radiation therapy, radiation biology studies using monochromatic beams, preclinical brain microsurgery, in-vitro phase contrast imaging (mammography, cartilage studies, etc.), functional imaging: bronchography (large volume or time resolved), and paleontology studies using 3D high-resolution imaging of samples requiring a wide beam (skulls, bones, etc.).