Publications describing MASSIF-1:

Please cite the appropriate references for experiments performed on MASSIF-1. An endnote library can be downloaded here

Svensson, O., Gilski, M., Nurizzo, D. & Bowler, M. W. (2018). Multi-position data collection and dynamic beam sizing: recent improvements to the automatic data-collection algorithms on MASSIF-1, Acta Cryst. D74, 433-440,

  • Describes the improvements made to the automatic data collection algorithms including dynamic adaptation of beam diameter to crystal volume and multi-position and helical data collection (MXPressP)

Svensson, O., Monaco, S., Popov, A. N., Nurizzo, D. & Bowler, M. W. (2015). The fully automatic characterization and data collection from crystals of biological macromolecules, Acta Cryst. D71, 1757-1767,

  • Describes the original developments in sample location, characterisation and data collection algorithms (automesh, X-ray centring, MXPressE and SAD data collection protocols etc.), should be cited for all experiments conducted on MASSIF-1 and those using X-ray centring

Bowler M.W., Nurizzo, D., Barrett, R., Beteva, A., Bodin, M., Caserotto, H., Delageniere, S., Dobias, F., Flot, D., Giraud, T., Guichard, N., Guijarro, M., Lentini, M., Leonard, G., McSweeney, S., Oskarsson, M., Schmidt, W., Snigirev, A., von Stetten, D., Surr, J., Svensson, O., Theveneau, P. and Mueller-Dieckmann, C. (2015) MASSIF-1: A beamline dedicated to the fully automatic characterisation and data collection from crystals of biological macromolecules J. Sync. Rad. 22 1540-1547

  • Describes the technical layout of the beamline, should be cited for all experiments conducted on MASSIF-1

Bowler, M.W., Svensson, O. & Nurizzo, D. (2016): Fully automatic macromolecular crystallography: the impact of MASSIF-1 on the optimum acquisition and quality of data, Cryst. Rev., 22, 233–249

  • Describes the first full year of operation of MASSIF-1, analysing the results from the large scale automation of MX data collection showing the advantages of fully autonomous data collection

Nurizzo, D., Bowler M.W., Caserotto, H., Dobias, F., Giraud, T., Surr, J., Guichard, N., Papp, G., Guijarro, M., Mueller-Dieckmann, C., Flot, D., McSweeney, S. Cipriani, F, Theveneau, P. and Leonard, G. (2016) RoboDiff: combining a sample changer and goniometer for highly automated macromolecular crystallography experiments Acta Cryst D 72, 966-975,

  • Describes the core robotic automation of the beamline

Svensson, O., Gilski, M., Nurizzo, D. & Bowler, M. W. (2019) A comparative anatomy of protein crystals: lessons from the automatic processing of 56,000 samples IUCrJ  6, 822-831

  • Describes the analysis of all the samples that have been sent to the beamline so far

Hutin, S., Van Laer, B., Mueller-Dieckmann, C., Leonard, G., Nurizzo, D., Bowler, M. W. (2019). Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules. J. Vis. Exp. 145, e59032, doi:10.3791/59032

  • A video article describing how to set up an experiment on the beamline


Publications that used data collected at MASSIF-1:


188. Bullen, G., Galson, J. D., Hall, G., Villar, P., Moreels, L., Ledsgaard, L., Mattiuzzo, G., Bentley, E. M., Masters, E. W., Tang, D., Millett, S., Tongue, D., Brown, R., Diamantopoulos, I., Parthiban, K., Tebbutt, C., Leah, R., Chaitanya, K., Ergueta-Carballo, S., Pazeraitis, D., Surade, S. B., Ashiru, O., Crippa, L., Cowan, R., Bowler, M. W., Campbell, J. I., Lee, W.-Y. J., Carr, M. D., Matthews, D., Pfeffer, P., Hufton, S. E., Sawmynaden, K., Osbourn, J., McCafferty, J. & Karatt-Vellatt, A. (2021). Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses, Frontiers in Immunology 12.

187. Gemenetzi, K., Psomopoulos, F., Carriles, A. A., Gounari, M., Minici, C., Plevova, K., Sutton, L.-A., Tsagiopoulou, M., Baliakas, P., Pasentsis, K., Anagnostopoulos, A., Sandaltzopoulos, R., Rosenquist, R., Davi, F., Pospisilova, S., Ghia, P., Stamatopoulos, K., Degano, M. & Chatzidimitriou, A. (2021). Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169, Blood 137, 1895-1904.

186. Clément, D. A., Leseigneur, C., Gelin, M., Coelho, D., Huteau, V., Lionne, C., Labesse, G., Dussurget, O. & Pochet, S. (2020). New Chemical Probe Targeting Bacterial NAD Kinase, Molecules 25, 4893.

185. Veerman, J. J. N., Bruseker, Y. B., Damen, E., Heijne, E. H., van Bruggen, W., Hekking, K. F. W., Winkel, R., Hupp, C. D., Keefe, A. D., Liu, J., Thomson, H. A., Zhang, Y., Cuozzo, J. W., McRiner, A. J., Mulvihill, M. J., van Rijnsbergen, P., Zech, B., Renzetti, L. M., Babiss, L. & Müller, G. (2021). Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors, ACS Medicinal Chemistry Letters.

184. Voegele, A., Sadi, M., O'Brien, D. P., Gehan, P., Raoux-Barbot, D., Davi, M., Hoos, S., Brûlé, S., Raynal, B., Weber, P., Mechaly, A., Haouz, A., Rodriguez, N., Vachette, P., Durand, D., Brier, S., Ladant, D. & Chenal, A. A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells, Advanced Science, 2003630.

183. Bellin, L., Del Caño-Ochoa, F., Velázquez-Campoy, A., Möhlmann, T. & Ramón-Maiques, S. (2021). Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase, Nature Communications 12, 947.

182. Du, J., Wrisberg, M.-K. v., Gulen, B., Stahl, M., Pett, C., Hedberg, C., Lang, K., Schneider, S. & Itzen, A. (2021). Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1, Nature Communications 12, 460.

181. Varaksa, T., Bukhdruker, S., Grabovec, I., Marin, E., Kavaleuski, A., Gusach, A., Kovalev, K., Maslov, I., Luginina, A., Zabelskii, D., Astashkin, R., Shevtsov, M., Smolskaya, S., Kavaleuskaya, A., Shabunya, P., Baranovsky, A., Dolgopalets, V., Charnou, Y., Savachka, A., Litvinovskaya, R., Hurski, A., Shevchenko, E., Rogachev, A., Mishin, A., Gordeliy, V., Gabrielian, A., Hurt, D. E., Nikonenko, B., Majorov, K., Apt, A., Rosenthal, A., Gilep, A., Borshchevskiy, V. & Strushkevich, N. (2021). Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis, Journal of Molecular Biology 433, 166763.

180. Delfosse, V., Huet, T., Harrus, D., Granell, M., Bourguet, M., Gardia-Parège, C., Chiavarina, B., Grimaldi, M., Le Mével, S., Blanc, P., Huang, D., Gruszczyk, J., Demeneix, B., Cianférani, S., Fini, J.-B., Balaguer, P. & Bourguet, W. (2021). Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures, Proceedings of the National Academy of Sciences 118, e2020551118.



179. van Tilburg, G. B. A., Murachelli, A. G., Fish, A., van der Heden van Noort, G. J., Ovaa, H. & Sixma, T. K. (2020). K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap, Cell Chemical Biology.

178. Voutilainen, S., Heinonen, M., Andberg, M., Jokinen, E., Maaheimo, H., Pääkkönen, J., Hakulinen, N., Rouvinen, J., Lähdesmäki, H., Kaski, S., Rousu, J., Penttilä, M. & Koivula, A. (2020). Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods, Applied Microbiology and Biotechnology 104, 10515-10529.

177. Beyer, H. M., Virtanen, S. I., Aranko, A. S., Mikula, K. M., Lountos, G. T., Wlodawer, A., Ollila, O. H. S. & Iwaï, H. (2020). The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms, International Journal of Molecular Sciences 21, 8367.

176. Liess, A. K. L., Kucerova, A., Schweimer, K., Schlesinger, D., Dybkov, O., Urlaub, H., Mansfeld, J. & Lorenz, S. (2020). Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S, Science Signaling 13, eaba8208.

175. Münzker, L., Petrick, J. K., Schleberger, C., Clavel, D., Cornaciu, I., Wilcken, R., Márquez, J. A., Klebe, G., Marzinzik, A. & Jahnke, W. (2020). Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase, Chembiochem : a European journal of chemical biology.

174. Ausar, S. F., Zhu, S., Duprez, J., Cohen, M., Bertrand, T., Steier, V., Wilson, D. J., Li, S., Sheung, A., Brookes, R. H., Pedyczak, A., Rak, A. & Andrew James, D. (2020). Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity, Communications Biology 3, 427.

173. Martinelli, L., Adamopoulos, A., Johansson, P., Wan, P. T., Gunnarsson, J., Guo, H., Boyd, H., Zelcer, N. & Sixma, T. K. (2020). Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate binding site, Journal of Biological Chemistry.

172. Waaler, J., Leenders, R. G. G., Sowa, S. T., Alam Brinch, S., Lycke, M., Nieczypor, P., Aertssen, S., Murthy, S., Galera-Prat, A., Damen, E., Wegert, A., Nazaré, M., Lehtiö, L. & Krauss, S. (2020). Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor, Journal of Medicinal Chemistry 63, 6834-6846.

171. Münzker, L., Petrick, J., Schleberger, C., Clavel, D., Cornaciu, I., Wilcken, R., Márquez, J. A., Klebe, G., Marzinzik, A. & Jahnke, W. Fragment-based discovery of non-bisphosphonate binders of Trypanosoma brucei farnesyl pyrophosphate synthase, ChemBioChem

170. Lee, Y., Warne, T., Nehmé, R., Pandey, S., Dwivedi-Agnihotri, H., Chaturvedi, M., Edwards, P. C., García-Nafría, J., Leslie, A. G. W., Shukla, A. K. & Tate, C. G. (2020). Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor, Nature.

169. Stutz, C. & Blein, S. (2020). A single mutation increases heavy chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species, Journal of Biological Chemistry.

168. Mais, C.-N., Hermann, L., Altegoer, F., Seubert, A., Richter, A. A., Wernersbach, I., Czech, L., Bremer, E. & Bange, G. (2020). Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase–deacetylase complex, Journal of Biological Chemistry.

167. Altegoer, F., Weiland, P., Giammarinaro, P. I., Freibert, S.-A., Binnebesel, L., Han, X., Lepak, A., Kahmann, R., Lechner, M. & Bange, G. (2020). The two paralogous kiwellin proteins KWL1 and KWL1-b from maize are structurally related and have overlapping functions in plant defense, Journal of Biological Chemistry 295, 7816-7825.

166. Bellenie, B. R., Cheung, K.-M. J., Varela, A., Pierrat, O. A., Collie, G. W., Box, G. M., Bright, M. D., Gowan, S., Hayes, A., Rodrigues, M. J., Shetty, K. N., Carter, M., Davis, O. A., Henley, A. T., Innocenti, P., Johnson, L. D., Liu, M., de Klerk, S., Le Bihan, Y.-V., Lloyd, M. G., McAndrew, P. C., Shehu, E., Talbot, R., Woodward, H. L., Burke, R., Kirkin, V., van Montfort, R. L. M., Raynaud, F. I., Rossanese, O. W. & Hoelder, S. (2020). Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders, Journal of Medicinal Chemistry 63, 4047-4068.

165. Dalle Vedove, A., Zonta, F., Zanforlin, E., Demitri, N., Ribaudo, G., Cazzanelli, G., Ongaro, A., Sarno, S., Zagotto, G., Battistutta, R., Ruzzene, M. & Lolli, G. (2020). A novel class of selective CK2 inhibitors targeting its open hinge conformation, European Journal of Medicinal Chemistry 195, 112267.

164. Khan, F., Kurre, D. & Suguna, K. (2020). Crystal structures of a β-trefoil lectin from Entamoeba histolytica in monomeric and a novel disulfide bond-mediated dimeric forms, Glycobiology 30, 474-488.

163. Dian, C., Pérez-Dorado, I., Rivière, F., Asensio, T., Legrand, P., Ritzefeld, M., Shen, M., Cota, E., Meinnel, T., Tate, E. W. & Giglione, C. (2020). High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation, Nature Communications 11, 1132.

162. Gunnell, E. A., Al-Noori, A., Muhsen, U., Davies, C. C., Dowden, J. & Dreveny, I. (2020). Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4), Biochemical Journal 477, 787-800.

161. Ashok, Y., Maksimainen, M. M., Kallio, T., Kilpeläinen, P. & Lehtiö, L. (2020). FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici, PLOS ONE 15, e0223870.

160. Henley, Z. A., Amour, A., Barton, N., Bantscheff, M., Bergamini, G., Bertrand, S. M., Convery, M., Down, K., Dümpelfeld, B., Edwards, C. D., Grandi, P., Gore, P. M., Keeling, S., Livia, S., Mallett, D., Maxwell, A., Price, M., Rau, C., Reinhard, F. B. M., Rowedder, J., Rowland, P., Taylor, J. A., Thomas, D. A., Hessel, E. M. & Hamblin, J. N. (2020). Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target, Journal of Medicinal Chemistry 63, 638-655.

161. Gelin, M., Paoletti, J., Nahori, M.-A., Huteau, V., Leseigneur, C., Jouvion, G., Dugué, L., Clément, D., Pons, J.-L., Assairi, L., Pochet, S., Labesse, G. & Dussurget, O. (2020). From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus, ACS Infectious Diseases.

160. Muir, K. W., Li, Y., Weis, F. & Panne, D. (2020). The structure of the cohesin ATPase elucidates the mechanism of SMC–kleisin ring opening, Nature Structural & Molecular Biology.

159. Alexander K.H. Weiss, Andreas Naschberger, Elia Cappuccio, Christina Metzger, Lorenza Mottes, Max Holzknecht, Jill von Velsen, Matthew W. Bowler, Bernhard Rupp, Pidder Jansen-Dürr, Structural and Functional Comparison of Fumarylacetoacetate Domain Containing Protein 1 (FAHD1) in Human and Mouse Biosci Rep BSR20194431. doi:

158. Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W. (2020). Phenylthiourea Binding to Human Tyrosinase-Related Protein 1, International Journal of Molecular Sciences 21, 915.

157. Liu, B., Trout, R. E. L., Chu, G.-H., McGarry, D., Jackson, R. W., Hamrick, J. C., Daigle, D. M., Cusick, S. M., Pozzi, C., De Luca, F., Benvenuti, M., Mangani, S., Docquier, J.-D., Weiss, W. J., Pevear, D. C., Xerri, L. & Burns, C. J. (2019). Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections, Journal of Medicinal Chemistry.

156. Li, Y., Haarhuis, J. H. I., Cacciatore, Á. S., Oldenkamp, R., van Ruiten, M. S., Willems, L., Teunissen, H., Muir, K. W., de Wit, E., Rowland, B. D. & Panne, D. (2020). The structural basis for cohesin–CTCF-anchored loops, Nature.


155. Chaugule, V. K., Arkinson, C., Rennie, M. L., Kämäräinen, O., Toth, R. & Walden, H. (2019). Allosteric mechanism for site-specific ubiquitination of FANCD2, Nature Chemical Biology.

154. Nicoll, C. R., Bailleul, G., Fiorentini, F., Mascotti, M. L., Fraaije, M. W. & Mattevi, A. (2019). Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs, Nature Structural & Molecular Biology.

153. Lefranc, J., Schulze, V. K., Hillig, R. C., Briem, H., Prinz, F., Mengel, A., Heinrich, T., Bálint, J., Rengachari, S., Irlbacher, H., Stöckigt, D., Bömer, U., Bader, B., Gradl, S. N., Nising, C. F., von Nussbaum, F., Mumberg, D., Panne, D. & Wengner, A. (2019). Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor, Journal of Medicinal Chemistry.

152. Trstenjak, N., Milić, D., Graewert, M. A., Rouha, H., Svergun, D., Djinović-Carugo, K., Nagy, E. & Badarau, A. (2019). Molecular mechanism of leukocidin GH–integrin CD11b/CD18 recognition and species specificity, Proceedings of the National Academy of Sciences 201913690.

151. Naschberger, A., Juyoux, P., von Velsen, J., Rupp, B. & Bowler, M. W. (2019). Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin, Acta Cryst. D 75, 1071-1083.

150. Banerjee, P., Chanchal & Jain, D. (2019). Sensor I Regulated ATPase Activity of FleQ Is Essential for Motility to Biofilm Transition in Pseudomonas aeruginosa, ACS Chemical Biology 14, 1515-1527.

149. Grobben, Y., Uitdehaag, J. C. M., Willemsen-Seegers, N., Tabak, W. W. A., Man, J. d., Buijsman, R. C. & Zaman, G. J. R. (2019). Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158, Journal of Structural Biology: X 100014.

148. Drulyte, I., Obajdin, J., Trinh, C. H., Kalverda, A. P., van der Kamp, M. W., Hemsworth, G. R. & Berry, A. (2019). Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase, IUCrJ 6.

147. de Groot, A., et al., Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. (2019), Nucleic Acids Research.

146. Cassotta, A., Mikol, V., Bertrand, T., Pouzieux, S., Le Parc, J., Ferrari, P., Dumas, J., Auer, M., Deisenhammer, F., Gastaldi, M., Franciotta, D., Silacci-Fregni, C., Fernandez Rodriguez, B., Giacchetto-Sasselli, I., Foglierini, M., Jarrossay, D., Geiger, R., Sallusto, F., Lanzavecchia, A. & Piccoli, L. (2019). A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients, Nature Medicine 25, 1402-1407.

145. Ohayon, D., De Chiara, A., Dang, P. M.-C., Thieblemont, N., Chatfield, S., Marzaioli, V., Burgener, S. S., Mocek, J., Candalh, C., Pintard, C., Tacnet-Delorme, P., Renault, G., Lagoutte, I., Favier, M., Walker, F., Hurtado-Nedelec, M., Desplancq, D., Weiss, E., Benarafa, C., Housset, D., Marie, J.-C., Frachet, P., El-Benna, J. & Witko-Sarsat, V. (2019). Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils, The Journal of Experimental Medicine jem.20180371.

144. Felix, J., Weinhäupl, K., Chipot, C., Dehez, F., Hessel, A., Gauto, D. F., Morlot, C., Abian, O., Gutsche, I., Velazquez-Campoy, A., Schanda, P. & Fraga, H. (2019). Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors, Science Advances 5, eaaw3818.

143. Banerjee, P., Chanchal & Jain, D. (2019). Sensor I Regulated ATPase Activity of FleQ Is Essential for Motility to Biofilm Transition in Pseudomonas aeruginosa, ACS Chemical Biology 14, 1515-1527.

142. Wang, H., Schoebel, S., Schmitz, F., Dong, H. & Hedfalk, K. (2019). Characterization of aquaporin-driven hydrogen peroxide transport, Biochimica et Biophysica Acta (BBA) - Biomembranes 183065.

141. Felix, J., Weinhäupl, K., Chipot, C., Dehez, F., Hessel, A., Gauto, D. F., Morlot, C., Abian, O., Gutsche, I., Velazquez-Campoy, A., Schanda, P. & Fraga, H. (2019). Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors, Science Advances 5, eaaw3818.

140. Medve, L., Achilli, S., Guzman-Caldentey, J., Thépaut, M., Senaldi, L., Le Roy, A., Sattin, S., Ebel, C., Vivès, C., Martin-Santamaria, S., Bernardi, A. & Fieschi, F. Enhancing potency and selectivity of a DC-SIGN glycomimetic ligand by fragment-based design: structural basis, Chemistry – A European Journal

139. Kersten, C., Fleischer, E., Kehrein, J., Borek, C., Jaenicke, E., Sotriffer, C. & Brenk, R. (2019). How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System, Journal of Medicinal Chemistry

138. Biterova, E. I., Isupov, M. N., Keegan, R. M., Lebedev, A. A., Sohail, A. A., Liaqat, I., Alanen, H. I. & Ruddock, L. W. (2019). The crystal structure of human microsomal triglyceride transfer protein, Proceedings of the National Academy of Sciences

137. Hassler, M., Shaltiel, I. A., Kschonsak, M., Simon, B., Merkel, F., Thärichen, L., Bailey, H. J., Macošek, J., Bravo, S., Metz, J., Hennig, J. & Haering, C. H. (2019). Structural Basis of an Asymmetric Condensin ATPase Cycle, Molecular Cell 74, 1175-1188.e1179.

136. Thouennon, E., Delfosse, V., Bailly, R., Blanc, P., Boulahtouf, A., Grimaldi, M., Barducci, A., Bourguet, W. & Balaguer, P. (2019). Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors, Cellular and Molecular Life Sciences.

135. Kumar, R., Oliver, C., Brun, C., Juarez-Martinez, A. B., Tarabay, Y., Kadlec, J. & de Massy, B. (2018). Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4, Life Science Alliance 1, e201800259.

134. Adamopoulos, A., Landskron, L., Heidebrecht, T., Tsakou, F., Bleijerveld, O. B., Altelaar, M., Nieuwenhuis, J., Celie, P. H. N., Brummelkamp, T. R. & Perrakis, A. (2019). Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1–SVBP, Nature Structural & Molecular Biology 26, 567-570.

133. Fang, W., Sanz, A. B., Bartual, S. G., Wang, B., Ferenbach, A. T., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D. M. F. (2019). Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases, Nature Communications 10, 1669.

132. Hafstrand, I., Sayitoglu, E. C., Apavaloaei, A., Josey, B. J., Sun, R., Han, X., Pellegrino, S., Ozkazanc, D., Potens, R., Janssen, L., Nilvebrant, J., Nygren, P.-Å., Sandalova, T., Springer, S., Georgoudaki, A.-M., Duru, A. D. & Achour, A. (2019). Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin, Proceedings of the National Academy of Sciences 116, 5055-5060.

131. Kouba, T., Drncová, P. & Cusack, S. (2019). Structural snapshots of actively transcribing influenza polymerase, Nature Structural & Molecular Biology. 26460470

130. Oukoloff, K., Coquelle, N., Bartolini, M., Naldi, M., Le Guevel, R., Bach, S., Josselin, B., Ruchaud, S., Catto, M., Pisani, L., Denora, N., Iacobazzi, R. M., Silman, I., Sussman, J. L., Buron, F., Colletier, J.-P., Jean, L., Routier, S. & Renard, P.-Y. (2019). Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, European Journal of Medicinal Chemistry 168, 58-77.

129. Cereija, T. B., Alarico, S., Lourenco, E. C., Manso, J. A., Ventura, M. R., Empadinhas, N., Macedo-Ribeiro, S. & Pereira, P. J. B. (2019). The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvation, IUCrJ 6.

128. Randich, A. M., Kysela, D. T., Morlot, C. & Brun, Y. V. (2019). Origin of a Core Bacterial Gene via Co-option and Detoxification of a Phage Lysin, Current Biology.

127. Raasakka, A., Linxweiler, H., Brophy, P. J., Sherman, D. L. & Kursula, P. (2019). Direct Binding of the Flexible C-Terminal Segment of Periaxin to β4 Integrin Suggests a Molecular Basis for CMT4F, Frontiers in Molecular Neuroscience 12.

126. Linciano, P., Pozzi, C., Iacono, L. d., di Pisa, F., Landi, G., Bonucci, A., Gul, S., Kuzikov, M., Ellinger, B., Witt, G., Santarem, N., Baptista, C., Franco, C., Moraes, C. B., Müller, W., Wittig, U., Luciani, R., Sesenna, A., Quotadamo, A., Ferrari, S., Pöhner, I., Cordeiro-da-Silva, A., Mangani, S., Costantino, L. & Costi, M. P. (2019). Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections, Journal of Medicinal Chemistry 62, 3989-4012.

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