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Fig. 138: a) HiP-CT of the brain and heart. At the highest resolution,

Purkinje cells and cardiac myocytes can be identified

(yellow arrows). b) The right upper lung lobe of a 54y/o

male who died of COVID-19. Partial segmentation shows

airways (cyan), large open vessels (red) and small

occluded vessels (yellow). c) Anastomosis between the

bronchial and pulmonary vascular systems (white

arrow) in the COVID-19 lung. d) Lung microstructure analysis from different

regions within the COVID-19 lung lobe (COVIDs and

COVIDc) and a control lung. Significant differences

between all groups for the mean distance between a lung tissue and air space.

Fig. 137: Diagram

showing the hierarchical structure of

the lung.

alignment of high-resolution to lower-resolution volumes can be performed with a simple manual rigid registration.

HiP-CT was successfully applied to five human parenchymal organ types: brain, lung, heart, spleen and

kidney. In each case, HiP-CT showed the expected organotypic features at each resolution. In the brain and heart, individual cells (Purkinje and myocytes respectively) could be identified within the intact organs at the highest resolutions (Figure 138a). Application of HiP-CT to a