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PRODID:-//Events Calendar//iCal4j 1.0//EN
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DTSTAMP:20260812T025732Z
DTSTART:20260709T140000
DTEND:20260709T150000
SUMMARY:EXPLORE ESRF BEAMLINES - BM07-FIP2: a versatile beamline for automated and functional macromolecular crystallography - Antoine Royant
UID:20260812T025732Z-uidGen@ovm-jahia-app1.esrf.fr
DESCRIPTION:REPLAY BM07-FIP2 Webinar ABSTRACT   BM07 is a French CRG beamline dedicated to macromolecular crystallography experiments\, built during the EBS shutdown as a successor to BM30A\, which was originally developed as a tuneable energy beamline to determine structures using anomalous signal-based techniques. With the advent of AI-based methods to determine protein structure de novo\, BM07 has initially focussed on optimising high-throughput screening of crystals maintained at cryogenic temperature\, and subsequent diffraction data collection. Besides\, the beamline now offers a portfolio of different techniques to study protein dynamics\, thanks to a new versatile goniometer. This includes data collection at different energies (6.5 – 20 keV)\, at various temperatures (from 80 to 333 K)\, under variable hydrostatic pressure (up to 50 kbar)\, and the use of UV-visible absorption and fluorescence emission spectroscopy as a complementary optical spectroscopy technique directly applied to the crystal placed on the diffractometer. Last\, time-resolved crystallography experiments can be performed on the second to minute timescale using either liquid substrate/cofactor dispensing or light activation in order to initiate reactions in enzymes or photosensitive proteins.
LOCATION:online
CATEGORIES:Webinar
LAST-MODIFIED:20260727T144546Z
URL:https://www.esrf.fr/cms/render/live/en/sites/www/home/events/Seminars/webinars/content/area-events/past-online-seminars/explore-esrf-beamlines-bm07-fip2-a-versatile-beamline-for-automated-and-functional-macromolecular-cr.html
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