Highlights: Structural biology

Mycoplasmas use molecular 'judo armlock' to evade host immune response
How a very “sociable” protein can hold clues about Alzheimer’s origin
X-ray diffraction reveals the stabilisation effects of a hyperstable engineered protein catalyst
An unusual blue jellyfish opens up doors to new fluorescent proteins
Radiation damage in serial protein X-ray crystallography
X-ray structure of malarial sugar transporter PfHT1 reveals the molecular basis for sugar specificity
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian flavin-containing monooxygenases
Modulation in the exit tunnel of the S. aureus ribosome leads to erythromycin resistance
X-linked intellectual disability related to a mutation in the catalytic domain of O-GlcNAc transferase
Adenovirus binding to its receptor visualised by cryo-EM
Liquid-liquid phase separation of Rubisco during carboxysome biogenesis in cyanobacteria
Structure of the human ferritin-transferrin receptor 1 complex
How cohesin ensures sister chromatids segregate correctly
Structural basis of membrane protein chaperoning through the mitochondrial intermembrane space
Crystal structure of a novel class of ubiquitin E3 ligase
Serial crystallography develops by leaps and bounds at the ESRF
Prevention of GroEL ring separation results in functionally defective symmetric GroEL:GroES2 complexes
Condensin complexes fasten the belt around DNA
Crystal structure of poxvirus DNA polymerase
Surface glycoprotein coat structure helps explain how trypanosomes avoid detection in their host
Coiled-coil protein-origami cages self-assemble in cells
Inauguration of a Cryo-electron microscope platform at the ESRF
Iodide as a universal tool for solving new structures of membrane proteins
Visualising how cell signalling takes place in microorganisms
The remarkable complexity of vitamin B6 biosynthesis
Joining back together the ends of broken DNA
Toxoplasma’s immunogenic balancing act explained
First structure and inhibitor of the emerging cancer target MTHFD2
The structure of an activated G protein coupled receptor bound to an engineered G protein
The birth of the brightest red glowing protein
Crystal structure of PolD provides a novel paradigm for the classification of DNA polymerases
#weekendusers Express experiments for better health
Structural basis of an unusual carbocyclisation in nogalamycin biosynthesis
High-pressure cryocooling of protein crystals reveals gas transport channels in a hydrogen-converting enzyme
3D structure sheds light on the mechanism of uromodulin self-polymerisation
How do breast milk components interact with human norovirus?
Where science never sleeps
Fully automatic data collection: a new tool for structural biologists
Visualising inhibition of the Nav1.7 pain channel
Exposing the ‘Achilles heel’ of dengue virus serotypes
Trapping a sliding clamp in action: how MutS activates MutL in DNA mismatch repair
RNA virus replication into ribonucleoproteins and its regulation elucidated from bunyavirus polymerase structure
Structures of archaeal tubulin-like proteins that control cell shape
Injector-based room-temperature serial crystallography of a membrane protein using synchrotron radiation
Deciphering enzyme evolution in antibiotic biosynthesis pathways
Structural basis of lesion recognition by Rad14 (XPA)
Elucidating the architecture of transcription factor IIIC
How chemicals can combine to form deadly cocktails from harmless components
Cellular sodium and potassium pumps light up optogenetics
Converging peptide- and DNA-nanotechnology: molecular self-assembly of peptide nucleic acids
Mechanistic clues from the structure of mitochondrial complex I
Structure and flexibility of endosomal Vps34 complex II
Exposing the ‘Achilles heel’ of dengue virus serotypes
Rpf2-Rrs1 complex in the biogenesis of the ribosome
RNA virus replication into ribonucleoproteins and its regulation elucidated from bunyavirus polymerase structure
MXCuBE2 defines a new paradigm in macromolecular crystallography beamline control
High pressure cooling of biological crystals without cryoprotection
Structures of PI4KIIIβ complexes show how the enzyme recruits Rab11 with its effectors
A molecular caliper for metered hormone response
Crystal structure of a common GPCR-binding interface for G-protein and arrestin
Insight into an intermediate step in O2-dependent catalysis
Tracking the bacterial immune system
Structural elucidation of MADS domain transcription factor SEPALLATA3
The crystal structure of human aquaporin 2
Structural basis for nuclear import of splicing factors
Structure of a mammalian serotonin receptor revealed by X-ray crystallography
A transporter caught in the act
A promiscuous intermediate underlies the evolution of single copy transcription factors
The “strong ARM” of SRP68 shapes the signal recognition particle
Light-induced opening of a phytochrome
Structural insights into viral RNA synthesis by influenza polymerase
Structure of membrane lipid modifying protein provides starting point for development of drugs to fight RNA viruses and malaria
A promiscuous intermediate underlies the evolution of single copy transcription factors
Volume-conserving trans-cis isomerisation pathways in photoactive yellow protein visualised by picosecond X-ray crystallography
Nucleotide specific bacterial mRNA ‘decapping’
How the chaperone FACT recognises histones H2A-H2B and mediates nucleosome reorganisation
Structure of gene regulator that plays key role in cancer
Long wavelength S-SAD phasing of the crystal structure of FAM3 PANDER reveals a new class of signalling molecules
The structure and function of a membrane protein involved in the adaptation to hyperosmotic shock
How the ribosome decodes a modified ‘wobble’ position anticodon for accurate protein translation
How arrestin is activated for GPCR binding
Solution structure of the hepatitis C virus IRES: an articulated RNA molecule involved in cap-independent translation initiation
Structural basis for stabilisation of Hsp70-substrate complexes by Hip
Structural basis for ion permeation in a pentameric ligand-gated ion channel revealed by X-ray crystallography
Structural analysis reveals the LxxLL motif hijacking strategy developed by papillomavirus E6 oncoproteins
X-ray snapshots of likely intermediates in the synthesis and degradation of biological Fe4S4 clusters
Crystal structure of the entire respiratory complex I
Cellular water transport: sub-angstrom resolution insights from the crystal structure of a membrane protein
Cellular water transport: atomic level insight provided by the first sub-angstrom resolution crystal structure of a membrane protein
A new class of signalling molecules revealed by structure solution exploiting the anomalous scattering of sulphur
Sub-angstrom resolution protein crystallography reveals how living organisms discriminate in favour of phosphate in arsenate-rich environments
Blue blood: a challenge for structural biologists
The dark side of KillerRed
Proteins shine a brighter light on cellular processes
Experimental procedure for the characterisation of radiation damage in macromolecular crystals
Tracking the protein motions that harvest energy
Structure of human complement iC3b revealed by 3D-electron microscopy and small-angle X-ray scattering
Structural and spectroscopic observation of an enzyme at work
Structures of SAS-6 suggest its organisation in centrioles
Nanobody aided crystallisation of β2m amyloidogenic intermediate
Structure of the membrane domain of respiratory complex I
The molecular details of receptor-drug interactions in the treatment of asthma and heart conditions
The structural basis of modularity in ECF-type ABC transporters
Development of a universal vaccine for Streptococcus agalactiae
Snapshot of a bacterial transporter in action
A RAF-induced allosteric transition of KSR stimulates KSR and RAF phosphorylation of MEK
Tail-anchored protein targeting to the endoplasmic reticulum membrane
TBL1, a tetrameric scaffold at the heart of the SMRT/NCoR transcriptional repression machinery
The molecular mechanism of pain relief
The Mre11/Rad50 complex - an ATP dependent molecular clamp in DNA double strand break repair
Ser or Leu: Structural impact of a genetic code alteration in C. albicans
How an oxygen-tolerant hydrogenase protects itself from oxygen
The molecular details of receptor-drug interactions in the treatment of asthma and heart conditions
Scientists defuse the Vietnam time bomb
Intruder alarm within our cells: RIG-I senses viral DNA
X-rays help advance the battle against heart disease
Snapshot of a bacterial transporter in the act of secreting a protein
Structural and spectroscopic observation of an enzyme at work
The structure of the Kinesin-1 motor-tail complex reveals the mechanism of autoinhibition
Structure of the membrane domain of respiratory complex I
Bio-SAXS at ID14-3: looking at proteins in their native state – a valuable complement to protein crystallography studies
The molecular mechanism of pain relief
How the quorum-quenching N-acyl homoserine lactone acylase PvdQ disrupts bacterial virulence
The structure of the nuclease domain of human cytomegalovirus DNA packaging terminase
Repairing breaks in DNA double strands: the structure of DNA-PKcs
Structure of the torque ring of the bacterial flagellar motor and the molecular basis for rotational switching
Binding of the signal peptide to the signal recognition particle
How a new class of antibiotic inhibits bacterial type IIA toposiomerases
Activating the AP2 clathrin adaptor complex
A prokaryotic transcription regulation mechanism involving allosteric coupling between intrinsically disordered domains
Discovery of a marine bacterial porphyranase: from gene to structure and beyond
Structural basis of DNA binding by human mitochondrial mTERF
Towards atomic resolution of the plant photosystem I supercomplex
N-myristoyl transferase inhibitors as new leads to treat neglected diseases
Remnant of a prebiotic machine functioning within the contemporary ribosome
Molecular basis of the alternating access model of membrane transport in a sodium-hydantoin transporter
Insight into the mechanism of spider silk assembly
Architecture of respiratory complex I: the “steam engine” of the cell?
Diffraction cartography: enhanced sample evaluation and data collection in macromolecular crystallography
Structural biology
How the "green light" is given for protein translation
I can sense your heartbeat
How a new class of antibiotic inhibits bacterial type IIA toposiomerases
Cell guidance mechanisms revealed at atomic-level resolution
Egg meets sperm: the female side of the story
The transition state of enzyme phosphoryl transfer revealed by magnesium triflouride
A snapshot of bacterial signalling
New drug candidates discovered for African sleeping sickness
Fluorescence of plant light-harvesting complex II in single crystals
Studies of UvrA2 provide insight into DNA binding and damage recognition
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
The structural basis of LPS recognition by the TLR4-MD-2 complex
Structure of a bacterial homologue of a ligand-gated ion channel
DNA Damage? Call 9-1-1
Complex between Neisseria meningitidis factor H binding protein and two domains from human complement factor H
Abundance of cofactors in photosystem II
Molecular basis for activation of Rho GTPases by DOCK guanine nucleotide exchange factors
Complement activation and regulation based on crystal structures of (C3bBb-SCIN)2 and C3b-factor H(1-4)
Structural biology
How the genetic code is accurately translated into protein
Meningitis bacteria stealth tactics revealed